can labs tell the difference between real and synthetic urine

Can Labs Tell the Difference Between Real and Synthetic Urine?

Can labs tell the difference between real and synthetic urine? Yes! Labs can often distinguish between actual and fake urine. Many factors can differentiate the two, including changes in chemical makeup, temperature, and pH levels. Furthermore, labs may apply specialized tests to detect the presence of particular chemicals or molecules often seen in synthetic urine. It’s worth noting that using synthetic urine to pass a drug test is banned everywhere.

What are the difference between real and synthetic urine?

Synthetic urine is produced in laboratories for various functions; it is manufactured in laboratories rather than by our bodies naturally. Synthetic urine is used for various purposes, one of which is to pass a drug test.

Individuals who want to pass a drug test must offer their urine. To pass the drug test, the urine must be free of any drug-related toxicants; nevertheless, some people’s urine may not be free. Therefore they contemplate purchasing a false urine sample created in labs.

Furthermore, synthetic urine is used by manufacturers of products such as diapers to test if the product is ready to be sold and if it performs effectively.

The distinction between real and synthetic urine is that genuine urine is produced naturally by human bodies, whereas synthetic urine is produced in laboratories. Unlike natural urine, synthetic urine changes color and has a distinct odor.

Also, the temperature of synthetic urine can vary, but natural urine has the same temperature as the typical body temperature, which ranges between 32° Celsius and 38° Celsius.

Here is a table for the difference between real and synthetic urine.

Real urineSynthetic urine
Real urine is produced by a living bodySynthetic urine is made from chemicals
Real urine is only used when there has to be a drug testSynthetic urine is used for products and can be used for drug tests
Real urine has a different smell and colorSynthetic urine may change in color or smell
Real urine temperature will be the same as the average body temperatureSynthetic urine temperature varies

Can labs tell the difference between real and synthetic urine?

Because of the similarities between synthetic urine and genuine urine, it might be hard to tell the difference. But the lab can tell the difference between real and synthetic urine.

Shaking a sample could expose false pee before current developments in urine faking technology because actual urine contains protein, which bubbles when agitated.

Some synthetic urine is protein-deficient. Sniffing works because urine includes microorganisms that produce odours and multiply the longer a sample is outside the body.

Novel formulations incorporating these proteins can pass muster as real urine, particularly if they have the same pure chemicals and density as real urine.

However, advances in research and drug testing technologies have allowed researchers to identify two compounds in synthetic urines not found in biological samples and use them as markers of invalidity, even when the creatinine, pH, and specific gravity met the current acceptance criteria.

How can a Lab tell if it’s synthetic or real urine?

It is nearly impossible to tell the difference between natural and fake pee by looking at them. This is because synthetic urine is created to have all of the naturally occurring compounds found in natural pee. However, labs may tell the difference between natural and synthetic urine in two ways:


If there is a temperature difference between synthetic and natural urine, a lab can easily determine that the urine sample is a forgery. The urine temperature should be between 32°C to 38°C, which corresponds to the typical body temperature.

Also, the color of synthetic urine and its odor differ from natural pee in various ways. This could imply that medical personnel are aware that the pee is synthetic. Always use a digitally controlled urinator device to keep pee at the proper temperature.


Chemical tests are another approach to determine whether a urine sample submitted to a laboratory is genuine or a forgery. Chemical tests are expensive and time-consuming, but they are performed if the lab members find your urine sample to be suspect in any way.

If it is determined that the urine sample was synthetic, you may be in big trouble. You would also be barred from taking the drug test again.

What happens if a Lab finds that the urine sample is synthetic and not natural?

Typically, laboratories do not conduct any special tests to establish whether the pee is natural or synthetic.

However, their knowledge in this employment sector provides them with a suggestion as to whether the urine sample is manufactured or purchased.

The color and odor of synthetic urine can be a crucial determinant in distinguishing it from genuine pee.

The greatest fake pee products for passing a urine drug test on short notice are Test clear dehydrated urine and Rapid Fix + 6.3 urine.

If a lab discovers that the urine sample submitted to them is not natural but synthetic, it will be discarded. They would classify it as “adulterated.”

Not only that but you will not be permitted to retake the test. You will not accept any type of urine sample after leaving the laboratory.

Furthermore, if your organization manages the complete drug test process, you will suffer a major loss of image and, most crucially, your job. As a result, it is always preferable to provide a natural urine sample for your drug test.

Can a lab tell if urine is mixed?

Yes! External adulteration is accomplished by introducing a material into the urine during the collecting process after the pee has been securely removed from the body. A lab can tell about mixed urine! Laboratories that use specimen “validity” or “adult-checks” can detect pre- and post-collection dilution.

Final Words

The labs should tell the difference between Real and Synthetic Urine. Because several firms demand prospective employees submit a urine drug test before hiring to check the drug issue. This test will reduce the likelihood of on-the-job accidents. For that, it’s very important!


"Hasan", I am a physiotherapy Doctor. I have completed my B.S.c course (4 years) under Rajshahi University, Faculty of Medicine, Rajshahi. Currently I am working as a clinical physiotherapist at a renowned physiotherapy center and I am continuing my MPT (Master's of physiotherapy) degree at CRP, Savar.

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